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KMID : 0387419990100020059
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Korean Society of Oriental Neuropsychiatry
1999 Volume.10 No. 2 p.59 ~ p.70
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Studies on the anti-inflammatory action of steamed Rehmannia glutinosa in central nervous system
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Jung Yong-Sik
Kang Hyung-Won
Lyu Yeoung-Su
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Abstract
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We investigated whether an aqueous extract of Rehmannia glutinosa steamed root (RGAE) inhibits secretion of inflammatory cytolanes from primary cultures of mouse astrocytes. RGAE dose-dependently inhibited the $TNF-{\alpha}$ secretion by astrocytes stimulated with substance P (SP) and lipopolysaccharide (LPS). Interleukin-1 (IL-1) has been shown to elevate $TNF-{\alpha}$ secretion from LPS-stimulated astrocytes while having no effect on astrocytes in the absence of LPS. We therefore also investigated whether IL-1 mediated inhibition of $TNF-{\alpha}$ secretion from primary astrocytes by RGAE. Treatment of RGAE to astrocytes stimulated with both LPS and SP decreased IL-1 secretion to the level observed with LPS alone. Moreover, incubation of astrocytes with IL-1 antibody abolished the synergistic cooperative effect of LPS and SP. These results suggest that RGAE has an antiinflammatory activity on the central nervous system curing some pathological disease states.
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KEYWORD
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Rehmannia glutinosa steamed root, Astrocytes, Tumor necrosis factor-a, Substance P, Lipopolyusaccharide, Interleukin-1
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